A survey of error-correction methods for next-generation sequencing
نویسندگان
چکیده
منابع مشابه
A survey of error-correction methods for next-generation sequencing
UNLABELLED Error Correction is important for most next-generation sequencing applications because highly accurate sequenced reads will likely lead to higher quality results. Many techniques for error correction of sequencing data from next-gen platforms have been developed in the recent years. However, compared with the fast development of sequencing technologies, there is a lack of standardize...
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Motivation Next-generation sequencing platforms have produced huge amounts of sequence data. This is revolutionizing every aspect of genetic and genomic research. However, these sequence datasets contain quite a number of machine-induced errors-e.g. errors due to substitution can be as high as 2.5%. Existing error-correction methods are still far from perfect. In fact, more errors are sometimes...
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15 صفحه اولAn Empirical Evaluation of Error Correction Methods and Tools for Next Generation Sequencing Data
Next Generation Sequencing (NGS) technologies produce massive amount of low cost data that is very much useful in genomic study and research. However, data produced by NGS is affected by different errors such as substitutions, deletions or insertion. It is essential to differentiate between true biological variants and alterations occurred due to errors for accurate downstream analysis. Many ty...
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Recent scientific discoveries that resulted from the application of next-generation DNA sequencing technologies highlight the striking impact of these massively parallel platforms on genetics. These new methods have expanded previously focused readouts from a variety of DNA preparation protocols to a genome-wide scale and have fine-tuned their resolution to single base precision. The sequencing...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2012
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbs015